Symbol
Name
ID

Tmprss6
transmembrane serine protease 6
MGI:1919003

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Hypochromic microcytic anemia	Anisocytosis	Poikilocytosis
Disease(s) Associated with TMPRSS6
microcytic anemia

Mouse Phenotypes

hematopoietic system phenotype

increased spleen weight

extramedullary hematopoiesis

anemia

microcytic anemia

abnormal erythrocyte morphology

decreased erythrocyte cell number

decreased hematocrit

decreased hemoglobin content

decreased mean corpuscular hemoglobin

decreased mean corpuscular hemoglobin concentration

decreased mean corpuscular volume

increased red blood cell distribution width

anisopoikilocytosis

microcytosis

increased CD11b-high dendritic cell number

increased Ly6C-positive mature NK cell number

decreased NK cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

reticulocytosis

decreased spleen iron level

Availability

Mouse Genotype

Tmprss6^hem8/Tmprss6^hem8

Tmprss6^msk/Tmprss6^msk

Tmprss6^{tm1b(EUCOMM)Wtsi}/Tmprss6^{tm1b(EUCOMM)Wtsi}

Tmprss6^tm1Dgen/Tmprss6^tm1Dgen

Tmprss6^tm1Otin/Tmprss6^tm1Otin

Tmprss6^hem8/Tmprss6^tm1Dgen

Tmprss6^tm1Dgen/Tmprss6⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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